A role for tumour necrosis factor-alpha in acute lymphatic filariasis.
Identifieur interne : 00BD42 ( Main/Exploration ); précédent : 00BD41; suivant : 00BD43A role for tumour necrosis factor-alpha in acute lymphatic filariasis.
Auteurs : B K Das [Inde] ; P K Sahoo ; B. RavindranSource :
- Parasite immunology [ 0141-9838 ] ; 1996.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs), Facteur de nécrose tumorale alpha (métabolisme), Filariose lymphatique (), Filariose lymphatique (immunologie), Filariose lymphatique (étiologie), Humains, Maladie aigüe, Médiateurs de l'inflammation (antagonistes et inhibiteurs), Médiateurs de l'inflammation (sang), Porteur sain (immunologie), Sujet âgé.
- MESH :
- antagonistes et inhibiteurs : Facteur de nécrose tumorale alpha, Médiateurs de l'inflammation.
- immunologie : Filariose lymphatique, Porteur sain.
- métabolisme : Facteur de nécrose tumorale alpha.
- sang : Médiateurs de l'inflammation.
- étiologie : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Filariose lymphatique, Humains, Maladie aigüe, Sujet âgé.
English descriptors
- KwdEn :
- Acute Disease, Adolescent, Adult, Aged, Carrier State (immunology), Elephantiasis, Filarial (etiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (therapy), Humans, Inflammation Mediators (antagonists & inhibitors), Inflammation Mediators (blood), Middle Aged, Tumor Necrosis Factor-alpha (antagonists & inhibitors), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Inflammation Mediators, Tumor Necrosis Factor-alpha.
- chemical , blood : Inflammation Mediators.
- etiology : Elephantiasis, Filarial.
- immunology : Carrier State, Elephantiasis, Filarial.
- chemical , metabolism : Tumor Necrosis Factor-alpha.
- therapy : Elephantiasis, Filarial.
- Acute Disease, Adolescent, Adult, Aged, Humans, Middle Aged.
Abstract
A spectrum of clinical manifestations is a feature of human lymphatic filariasis. The acute disease is characterized by periodic and self limiting episodes of adenolymphangitis, fever and associated constitutional symptoms, while the chronic disease includes long lasting manifestations such as lymphoedema and/or hydrocoele. The microfilariae carriers are generally free of clinical symptoms. In the present study circulating Tumour Necrosis Factor (TNF-alpha) was measured in human bancroftian filariasis with different clinical manifestations. Significantly elevated levels were observed only in patients with acute disease and not in microfilariae carriers or in patients with chronic manifestations. A detailed analysis of the acute cases indicated an absence of correlation between TNF-alpha levels and duration of the episodes. However, a significant positive correlation was observed between the severity of the disease and the TNF-alpha levels. About 85% of the acute cases with severe manifestations showed raised levels of TNF-alpha while only 6.5% of mild cases showed such levels. Manifestation of fever was also significantly associated with higher levels of TNF-alpha-while 80% of acute cases with fever had significant levels only 24% of acute cases without fever had high levels of TNF-alpha. Based on these observations we propose a mediatory role for TNF-alpha in acute filariasis and the possible use of TNF-alpha inhibitors for clinical management of the disease.
PubMed: 9229396
Affiliations:
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Ravindran</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Carrier State (immunology)</term><term>Elephantiasis, Filarial (etiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (therapy)</term><term>Humans</term><term>Inflammation Mediators (antagonists & inhibitors)</term><term>Inflammation Mediators (blood)</term><term>Middle Aged</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs)</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (étiologie)</term><term>Humains</term><term>Maladie aigüe</term><term>Médiateurs de l'inflammation (antagonistes et inhibiteurs)</term><term>Médiateurs de l'inflammation (sang)</term><term>Porteur sain (immunologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Inflammation Mediators</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Médiateurs de l'inflammation</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Porteur sain</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carrier State</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Médiateurs de l'inflammation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Filariose lymphatique</term><term>Humains</term><term>Maladie aigüe</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A spectrum of clinical manifestations is a feature of human lymphatic filariasis. The acute disease is characterized by periodic and self limiting episodes of adenolymphangitis, fever and associated constitutional symptoms, while the chronic disease includes long lasting manifestations such as lymphoedema and/or hydrocoele. The microfilariae carriers are generally free of clinical symptoms. In the present study circulating Tumour Necrosis Factor (TNF-alpha) was measured in human bancroftian filariasis with different clinical manifestations. Significantly elevated levels were observed only in patients with acute disease and not in microfilariae carriers or in patients with chronic manifestations. A detailed analysis of the acute cases indicated an absence of correlation between TNF-alpha levels and duration of the episodes. However, a significant positive correlation was observed between the severity of the disease and the TNF-alpha levels. About 85% of the acute cases with severe manifestations showed raised levels of TNF-alpha while only 6.5% of mild cases showed such levels. Manifestation of fever was also significantly associated with higher levels of TNF-alpha-while 80% of acute cases with fever had significant levels only 24% of acute cases without fever had high levels of TNF-alpha. Based on these observations we propose a mediatory role for TNF-alpha in acute filariasis and the possible use of TNF-alpha inhibitors for clinical management of the disease.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Ravindran, B" sort="Ravindran, B" uniqKey="Ravindran B" first="B" last="Ravindran">B. Ravindran</name><name sortKey="Sahoo, P K" sort="Sahoo, P K" uniqKey="Sahoo P" first="P K" last="Sahoo">P K Sahoo</name></noCountry><country name="Inde"><noRegion><name sortKey="Das, B K" sort="Das, B K" uniqKey="Das B" first="B K" last="Das">B K Das</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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